Ketamine and Stress in OCD
Randomized, double-blind, comparator-controlled crossover trial (n=30) testing low-dose IV ketamine (0.5 mg/kg, 40 min infusion) versus midazolam in patients with OCD at the Medical University of Vienna.
Details
Randomized, double-blind, triple-masked crossover study comparing a single IV ketamine infusion (0.5 mg/kg over 40 minutes) with midazolam in adults with primary OCD; sequences separated by a 14-day washout and stratified by baseline YBOCS severity.
Outcomes include acute and short-term anti-OCD effects, neurocognitive performance on four tasks, stress responsivity using a cold pressor test, and EEG measures during and after infusions.
An optional open-label continuation offers up to eight ketamine infusions over a month compared with treatment-as-usual; additional EEG assessment follows completion of open-label treatment.