This proposed single-centre, double-blinded, randomized clinical trial of adult patients with depression presenting for gynaecologic surgery compares severity of depressive symptoms between patients receiving and not receiving ketamine as part of their general anaesthetic (n=50).
Randomised, triple-masked, parallel-group trial comparing standard induction (propofol + fentanyl) versus induction with added ketamine hydrochloride 0.5 mg/kg in adults with major depressive disorder presenting for gynaecologic surgery.
Primary aim is to compare postoperative depressive symptom severity; secondary outcomes include safety/tolerability and perioperative physiological measures.
Propofol and fentanyl as part of the patient's anaesthetic induction.
Propofol administered as part of anaesthetic induction.
Fentanyl administered as part of anaesthetic induction.
Propofol and fentanyl plus ketamine hydrochloride (co‑induction) as part of the patient's anaesthetic induction.
Ketamine hydrochloride 0.5 mg/kg added to induction.
Propofol administered as part of anaesthetic induction.
Fentanyl administered as part of anaesthetic induction.