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Ketamine Co-induction for Patients With Major Depressive Disorder

Unknown statusRegisteredCTG

This proposed single-centre, double-blinded, randomized clinical trial of adult patients with depression presenting for gynaecologic surgery compares severity of depressive symptoms between patients receiving and not receiving ketamine as part of their general anaesthetic (n=50).

Details

Randomised, triple-masked, parallel-group trial comparing standard induction (propofol + fentanyl) versus induction with added ketamine hydrochloride 0.5 mg/kg in adults with major depressive disorder presenting for gynaecologic surgery.

Primary aim is to compare postoperative depressive symptom severity; secondary outcomes include safety/tolerability and perioperative physiological measures.

Topics:Major Depressive Disorder (MDD)

Registry

Registry linkNCT03666494