Ketamine for Depression and Alcohol Dependence

Proof-of-concept study assessing the effect of a single intravenous ketamine infusion (0.5 mg/kg over 40 minutes) on depressive symptoms in patients with current major depressive episode and alcohol dependence.

Primary outcome planned as change in depression rating at 72 hours; alcohol consumption and safety/AE monitoring are secondary outcomes. Registry fragments list a single-group intervention with actual enrolment of 5.