The investigators hope to see if a commonly used drug such as ketamine could help depressed ER patients feel better and improve their mood quickly.
Open-label, single-group Phase I study in Emergency Department patients (n=14) testing a single IV sub-anaesthetic ketamine dose (0.2 mg/kg over 1–2 minutes) for rapid antidepressant effects and reduction in suicide ideation; patients monitored for 4 hours post-dose.
The published manuscript was later retracted after a Yale investigation found that the protocol-specified doses and the actual delivered doses of ketamine were misrepresented.
Single sub-anaesthetic IV bolus of ketamine (0.2 mg/kg over 1–2 min) with 4 h monitoring.
0.2 mg/kg administered over 1–2 minutes; monitored for 4 h post-dose.