Pilot double-blind, placebo-controlled randomised clinical trial (n=50) testing a single IV ketamine infusion (0.8 mg/kg over 40 minutes) versus saline in adults with severe alcohol use disorder seeking inpatient detoxification in the ED to assess safety and preliminary efficacy.
Randomised, triple-blind, parallel-group trial comparing a single IV ketamine infusion (0.8 mg/kg, 40 minutes) with saline placebo in individuals presenting to the ED for inpatient alcohol detoxification; primary aim is safety.
Secondary measures include alcohol use outcomes (TLFB abstinent days, days to relapse, heavy drinking days), engagement with addiction treatment, urine ketamine, and alcohol biomarkers at 28 days.
Single IV ketamine infusion 0.8 mg/kg over 40 minutes (n=25).
Infusion over 40 minutes in ED.
Saline placebo 0.9% infusion over 40 minutes (n=25).
0.9% saline infused over 40 minutes.