Ketamine Interleaved With Electroconvulsive Therapy for Depression

Pragmatic randomised parallel-group pilot comparing twice-weekly sub-anaesthetic ketamine infusions (0.5 mg/kg) with midazolam (0.045 mg/kg) as adjuncts to an ECT course; infusions administered by a consultant anaesthetist with first infusion after the first or second ECT.

Outcomes include physical, psychotomimetic and cognitive measures assessed during and after infusions, with follow-up at six weeks and three months to assess relapse; treatment-as-usual continued throughout.