Randomised, double-blind, parallel study comparing brief pulse ECT with ketamine infusion (0.5 mg/kg) versus ECT with saline in patients with major depression to assess clinical response and cognitive side effects.
Randomised, double-blind, parallel-group trial comparing brief pulse ECT plus ketamine infusion (0.5 mg/kg) versus ECT plus saline placebo on depressive symptoms.
Secondary outcomes include cognitive impairment, quality of life, BDNF levels and associations with 25-hydroxyvitamin D.
Brief pulse ECT with saline placebo infusion in each session.
Saline infusion in each ECT session.
Brief pulse ECT with ketamine infusion in each session.
Ketamine infusion (0.5 mg/kg) in each ECT session.