Double-blind, randomised crossover fMRI study (n=37) testing a single IV ketamine infusion (0.5 mg/kg over 40 min) versus saline in remitted depressed volunteers to examine early antidepressant effects on rumination and reward-related brain activity.
This double-blind, randomised crossover study examines acute (2-hour) antidepressant effects of a single 0.5 mg/kg IV ketamine infusion versus saline in remitted depressed participants using fMRI tasks probing autobiographical emotional memory (rumination) and monetary reward (anhedonia).
Outcomes include changes in limbic and striatal activation during tasks, with secondary assessment of safety and tolerability; sessions are separated by a minimum 1-week washout.
Ketalar (ketamine) single intravenous steady-state infusion over 40 min.
Single IV infusion over 40 minutes (0.5 mg/kg).
Intravenous saline placebo comparator, steady-state infusion over 40 min.
Saline IV infusion over 40 minutes (placebo comparator).