Low-dose Ketamine and Postpartum Depression in... — Clinical Trial Details

Randomized, double-arm, placebo-controlled trial testing whether a single low-dose ketamine infusion given after childbirth during elective cesarean delivery reduces incidence of postpartum depression in parturients with prenatal depression (EPDS ≥10).

Participants receive either ketamine 0.5 mg/kg in 100 ml normal saline or placebo (100 ml normal saline) infused IV over 40 minutes after delivery; outcomes include postpartum depression incidence and safety measures.

Inclusion Criteria:
Parturients with age from 18 to 45 years and scheduled for elective cesarean delivery;
Prenatal depression score (EPDS) of 10 or higher;
Provide written informed consents.

Exclusion Criteria:
Refused to participate in the study;
History of schizophrenia or other disease that prevent normal communication before delivery;
Presence of contraindications to neuraxial anesthesia, including central nervous system diseases (such as poliomyelitis), spinal diseases (such as spinal canal tumor, lumbar disc prolapse, history of spinal trauma), systemic infection (such as sepsis, bacteremia), local infection in the site of puncture, or coagulopathy;
Severe complications during pregnancy (such as severe preeclampsia, placenta accreta, HELLP syndrome);
Severe comorbidity before pregnancy (such as severe cardiac dysfunction);
Scheduled to undergo cesarean delivery under general anesthesia;
Other reasons that are considered unsuitable for study participation.

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Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression

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Ketamine

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Placebo

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Inclusion Criteria

Exclusion Criteria

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