Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression

Randomized, double-arm, placebo-controlled trial testing whether a single low-dose ketamine infusion given after childbirth during elective cesarean delivery reduces incidence of postpartum depression in parturients with prenatal depression (EPDS ≥10).

Participants receive either ketamine 0.5 mg/kg in 100 ml normal saline or placebo (100 ml normal saline) infused IV over 40 minutes after delivery; outcomes include postpartum depression incidence and safety measures.