MDMA and memory

This double‑blind, placebo‑controlled crossover study assessed the acute effects of a single 75 mg oral dose of MDMA on prospective and verbal memory during fMRI.

Twelve recreational MDMA users completed MDMA and placebo sessions with behavioural memory tasks and BOLD fMRI measured between 1.5 and 2.5 hours post‑dose to identify neural correlates of memory impairment.

Primary outcomes were prospective and verbal memory performance and related BOLD responses; secondary outcomes included reaction time and number of correct responses.