Mindfulness and Psychedelics
This double-blind, placebo-controlled trial (n=40) aims to investigate the potential neurophysiological synergy effects between mindfulness meditation and psychedelics, particularly Ayahuasca, on experienced meditators.
Details
Randomized, double-blind, quadruple-masked, parallel-group study in experienced meditators comparing an oral DMT+h arm with an organoleptically matched placebo during a three-day meditation retreat.
Primary measures include pre- and post- retreat functional MRI to assess network activity and connectivity, psychometric assessments, and detailed experiential interviews to probe neurophenomenology and subjective effects.
Participants are healthy adult meditators (≥1000 hours practice), BMI 18.5–35, randomized to receive a single oral administration of purified DMT plus harmine or placebo during the sitting meditation on day two; neither participants nor investigators are aware of assignment.