Molecular Imaging Study of Harmine/DMT: a Basic Research Approach (HaD-PET)

This study assesses acute changes in cerebral metabolic rate for glucose (CMRglc) measured with quantitative FDG-PET before and after administration of an oral harmine+DMT formulation compared with placebo in healthy male volunteers.

Randomised crossover design with two single-dose study days per participant; secondary analyses will correlate time-dependent PET measures with self-reported intensity of the psychedelic experience.