Neural Circuit Effects of Ketamine in Depression

This study examines the role of the subgenual anterior cingulate cortex (sgACC) in anhedonia and anxiety in people with MDD and measures acute and sustained effects of a single IV ketamine infusion on sgACC activation and depressive symptoms.

Randomized, parallel-group design (ketamine versus saline placebo); outcomes include neuroimaging measures of sgACC activation, clinical ratings of anhedonia and anxiety, and safety/tolerability assessments.