Neurobiology and Pharmacokinets of Acute MDMA Administration
Randomised, double-blind, within-subject crossover study (n=187) examining acute MDMA effects and pharmacokinetics at placebo, 1.0 mg/kg and 1.6 mg/kg with concurrent fMRI and biological sampling.
Details
This study evaluates MDMA effects on brain function using fMRI alongside detailed pharmacokinetic sampling in blood, urine, oral fluid, sweat, breath and hair to relate plasma concentrations to cognitive and neural changes.
A randomized, balanced, double-blind within-subject design compares placebo, low (1.0 mg/kg) and high (1.6 mg/kg) MDMA across three scanning sessions; participants perform memory, attention and decision-making tasks during scanning.
Pharmacokinetic goals include characterising MDMA and metabolite disposition across matrices to improve interpretation of drug tests and inform safety and forensic applications.