Neuronal Correlates of Altered States of Consciousness (5HT2A-fMRI)
Randomised, two-period crossover fMRI study (n=24) in healthy volunteers comparing single oral LSD (100 µg) with placebo to assess neuronal correlates of altered consciousness.
Details
This study uses a random-order two-period crossover design in healthy volunteers to compare normal and pharmacologically induced altered states of consciousness using fMRI.
Altered states are induced with a single oral dose of LSD (100 µg) versus an identical-appearing mannitol placebo; subjective alterations will be correlated with objective imaging measures to identify neuronal correlates of psychotic-like perception changes.
Outcomes inform the relationship between subjective phenomenology and brain activation patterns, with implications for understanding early schizophrenia and consciousness research.