This Phase IV, placebo-controlled crossover trial (n=35) will investigate the impact of ketamine on perceptual decision-making in healthy volunteers.
Randomised, blinded crossover in healthy volunteers comparing a single subcutaneous ketamine injection (0.7 mg/kg) with saline placebo, separated by a one-week washout.
Participants complete baseline and pre/post testing questionnaires and perform a perceptual decision-making task to assess accuracy and effects of ketamine on decision processes.
Single subcutaneous ketamine injection (active arm) in a two-period crossover with one-week washout.
Subcutaneous abdominal injection (0.7 mg/kg).
Saline abdominal injection of equivalent volume (placebo) in crossover.
Saline subcutaneous injection of equivalent volume to ketamine condition.