This randomised controlled Phase II trial (n=24) evaluated the safety and efficacy of ketamine for anorexia nervosa depressive disorder anxiety disorder obessional disorder using 26mg/70kg ketamine.
We will investigate if patients with long-standing anorexia nervosa show improvements in mood, obsessionality ratings, or eating disorder cognitions after oral dosing with ketamine or midazolam, a psychoactive control. In the first 3 weeks, patient will receive one of 2 doses of ketamine, or a single dose of midazolam, under double-blind, crossover conditions. Patient who report improvements in depression or anxiety ratings will be eligible to enter a maintenance treatment phase, where they can receive oral ketamine 1-2 times weekly for 3 months.