Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter

This study uses [11C]DASB PET to measure serotonin transporter binding after intravenous ketamine (multiple substudies including a main randomized double-blind esketamine vs saline comparison and several pilot dosing regimens of R,S- and S-ketamine).

Outcomes include PET SERT binding measures and the relationship between ketamine-induced SERT changes and antidepressant efficacy in severely depressed patients; multiple dosing regimens include bolus+infusion and single infusions timed before PET acquisition.