Precision Functional Brain Mapping in Psilocybin
Randomized, single-blind, crossover neuroimaging study (n=11) comparing single-dose psilocybin 25 mg vs methylphenidate 40 mg in healthy adults to map acute and 1-week effects on functional brain networks.
Details
This study uses precision functional mapping (PFM) and extended resting-state and task fMRI to characterise acute and sustained effects of 5-HT2A receptor agonism on cortical and cortico-subcortical networks in healthy adults.
A randomized, controlled crossover design has participants receive either psilocybin 25 mg oral capsule or methylphenidate 40 mg at two separate drug imaging sessions with a two-week washout, plus baseline and between-session imaging visits (up to five imaging sessions total).
PFM approach includes extended fMRI acquisition, aggressive data cleaning, and individual-level functional connectivity analyses to map drug-induced circuit changes and inform future clinical studies.