This Phase IV trial (n=40) investigates if a placebo is non-inferior to ketamine in treating chronic pain and depression when delivered under sedation (with propofol).
The goal of this clinical trial is to compare ketamine to a placebo when given as a single infusion during IV sedation in adults with chronic pain and depression. We do not know whether ketamine will be more effective than placebo under these circumstances.
This study aims to:
Participants will:
Single IV infusion of ketamine 0.5 mg/kg over 40 minutes, administered while the participant is under propofol sedation to preserve blinding.
Single IV infusion of 0.9% normal saline over 40 minutes, administered while the participant is under propofol sedation — propofol is given to both arms to keep participants blinded to treatment.
0.9% NaCl saline, volume-matched to ketamine arm.