Early Phase I randomised crossover study (n=33 actual) testing whether MDMA (100 mg) produces greater prosocial effects when administered with a familiar versus unfamiliar partner in healthy volunteers.
This randomised, triple-masked crossover study tests whether MDMA (100 mg) increases prosocial effects more when a participant interacts with a familiar partner than an unfamiliar one.
Familiarity is induced using a 45-minute structured conversation task (deep-talk versus small-talk) shown to increase feelings of closeness; after drug or placebo participants engage in a 15-minute conversation with the familiar or unfamiliar partner.
Outcomes assess prosocial mood and socio-emotional function; the study is a mechanistic laboratory investigation in healthy volunteers rather than a psychotherapy trial.
Participant interacts with a familiar partner after placebo.
Dextrose placebo
Participant interacts with a familiar partner after MDMA 100 mg (single dose).
Participant interacts with an unfamiliar partner after placebo.
Dextrose placebo
Participant interacts with an unfamiliar partner after MDMA 100 mg (single dose).