Psilocybin Therapy for Chronic Low Back Pain

This study evaluates whether psilocybin therapy helps patients cope with chronic low back pain more effectively. Procedures occur at UCSF; participants receive two preparation sessions, a single dosing session (6–8 hours), three integration sessions, and follow-up visits.

Four parallel arms compare single-dose psilocybin (1–30 mg, oral) combined with zolpidem and modafinil, zolpidem alone, modafinil alone, or placebo. Outcomes include pain-related distress, functioning, mood and safety.