Psilocybin TRD Feasibility RCT

This is a randomised, placebo-controlled feasibility study to test trial procedures, collect safety data and estimate sample size for a definitive trial of psilocybin with psychological support in treatment-resistant depression.

Participants meet DSM-5 criteria for major depressive disorder of at least moderate severity and have failed multiple antidepressant treatments; outcomes include safety, feasibility metrics and depressive symptom change (e.g., HAM-D).