Randomised, double-blind, placebo-controlled crossover study (n=16) comparing single 200 µg oral LSD vs placebo in healthy adults to characterise acute physiological, endocrine and pharmacokinetic responses and assess long-term psychological effects.
Randomised, double-blind, placebo-controlled crossover with two experimental sessions per subject (placebo and LSD). Subjective and cardiovascular responses were assessed repeatedly and plasma samples collected for pharmacokinetics and endocrine measurements.
The primary aim was to characterise acute psychological, physiological, endocrine and pharmacokinetic effects of a single 200 µg oral LSD dose in healthy volunteers; long-term psychological changes were also assessed.
Randomised double-blind placebo-controlled crossover; within-subject placebo and LSD sessions.
Single 200 µg oral LSD session.
Mannitol placebo capsule, identical appearance.