Psychological, Physiological, Endocrine, and Pharmacokinetic Effects of LSD in a Controlled Study

Randomised, double-blind, placebo-controlled crossover with two experimental sessions per subject (placebo and LSD). Subjective and cardiovascular responses were assessed repeatedly and plasma samples collected for pharmacokinetics and endocrine measurements.

The primary aim was to characterise acute psychological, physiological, endocrine and pharmacokinetic effects of a single 200 µg oral LSD dose in healthy volunteers; long-term psychological changes were also assessed.