Clinical TrialDepressive DisordersPlaceboPlaceboCompleted

Psyrreal VR Psychedelic Replication Feasibility Study — Estonia 2021

TBD

Ask Blossom about this trial
Target Enrollment
14 participants
Study Type
Phase NA interventional
Design
Non-randomized

Detailed Description

TBD

Study Arms & Interventions

Control VR

placebo

A 5-minute demonstrative VR experience in a small room with a balcony view onto a mountain range, used as a control condition for comparisons with EDI, PIQ, and MEQ30 measures.

Interventions

  • Placebo
    • single dose• 1 doses total

    5-minute demonstrative VR experience

Psyrreal VR

experimental

A 45-minute psychedelic-inspired virtual reality experience implementing various audiovisual and narrative phenomenological elements.

Interventions

  • Placebo
    • single dose• 1 doses total

    45-minute VR experience implemented on the second day of a 2-day intervention

Study Details

  • Status
    Completed
  • Phase
    Phase NA
  • Type
    interventional
  • Design
    Non-randomized
  • Target Enrollment14 participants
  • Timeline
    Start: 2022-01-01
    End: 2022-01-01
  • Compounds
    PlaceboPlacebo
  • Topic
    Depressive Disorders

Locations

Estonia

Related Publications

Open AccessindividualPrimary

Psychedelic replications in virtual reality and their potential as a therapeutic instrument: an open-label feasibility study

This open‑label feasibility study tested Psyrreal, a virtual reality experience that mimics psychedelic phenomenology, in 13 people with mild-to-moderate depression and found a significant reduction in depressive symptoms at 2‑week follow‑up (n = 10, p = 0.007, Hedges’ g = 1.046). Semi‑structured interviews suggested the VR sessions could produce insight and alterations in sense of self for some participants, indicating VR psychedelic replications with psychological support are a promising therapeutic approach warranting further controlled research.

Published
Journal
Frontiers in Psychiatry
Authors
Kaup, K. K., Vasser, M., Tulver, K., Aaru, J., Pikame, J.