Psyrreal VR Psychedelic Replication Feasibility Study — Estonia 2021

Psychedelic replications in virtual reality and their potential as a therapeutic instrument: an open-label feasibility study

This open‑label feasibility study tested Psyrreal, a virtual reality experience that mimics psychedelic phenomenology, in 13 people with mild-to-moderate depression and found a significant reduction in depressive symptoms at 2‑week follow‑up (n = 10, p = 0.007, Hedges’ g = 1.046). Semi‑structured interviews suggested the VR sessions could produce insight and alterations in sense of self for some participants, indicating VR psychedelic replications with psychological support are a promising therapeutic approach warranting further controlled research.

Published

March 1, 2023

Journal

Frontiers in Psychiatry

Authors

Kaup, K. K., Vasser, M., Tulver, K., Aaru, J., Pikame, J.