Rapid Antidepressant Effects of Ketamine in Major Depression

Double-blind, randomised, crossover trial in adults with treatment-resistant major depressive disorder assessing rapid antidepressant effects of a single intravenous ketamine infusion compared with saline placebo.

Primary endpoint: change in clinical depression ratings within one day; secondary analyses include neurobiological correlates via multimodal MRI, MEG, polysomnography and serum markers.