Clinical TrialCompleted

Effects of Nitrous Oxide Augmentation of the Selective Serotonin Reuptake Inhibitors Treatment of Major Depressive Disorder

Double-blind randomized parallel-group trial of adjunctive nitrous oxide (50% N2O/50% O2, 60 min twice weekly for 4 weeks; n=12) vs placebo (100% O2, same schedule; n=11) added to stable SSRI treatment in MDD patients aged 18–65 with HDRS-17 > 17. Primary outcome: HDRS-17 change from baseline. Sponsor: Hospital das Clínicas FMRP-USP, Ribeirão Preto, Brazil.

Target Enrollment
23 participants
Study Type
Phase I/II interventional
Design
Randomized, double Blind

Study Details

  • Status
    Completed
  • Phase
    Phase IPhase II
  • Type
    interventional
  • Design
    Randomizeddouble Blind
  • Target Enrollment23 participants
  • Timeline
    Start: 2016-06-10

Related Publications

Nitrous oxide as an adjunctive therapy in major depressive disorder: a randomized controlled double-blind pilot trial

Published
Authors
Guimarães, M. C., Guimarães, T. M., Hallak, J. E., Abrão, J., Machado-de-Sousa, J. P.

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