Repeated Ketamine Infusions for Comorbid PTSD and MDD in Veterans
Randomised, double-blind, placebo-controlled parallel trial (n=67) of six IV ketamine infusions (0.5 mg/kg) over 3 weeks in veterans with comorbid PTSD and MDD to probe neuroanatomy and executive functioning.
Details
This randomised, double-blind, placebo-controlled parallel trial will enrol veterans with chronic comorbid PTSD and MDD and randomise them to six intravenous ketamine infusions (0.5 mg/kg) or normal saline over three weeks to investigate neuroanatomical and executive-function mechanisms using fMRI and neurocognitive testing.
Participants remain onsite for approximately two hours after each infusion, are contacted by phone the following day, and undergo a follow-up fMRI and four visits up to two months; additional healthy control, depression-only, and PTSD-only cohorts undergo baseline assessments including a single fMRI.