Randomised, double-blind, parallel healthy volunteer study (n=70) testing a single IV ketamine infusion (0.5 mg/kg) versus placebo to examine effects on reward learning and memory.
This parallel, randomised, double-blind study in healthy volunteers examines how a single antidepressant dose of ketamine (0.5 mg/kg IV) alters reward-emotion learning and memory compared with placebo.
Participants complete tasks assessing learning about reward and punishment and memory for learned reward associations, with neural measures collected to characterise mechanisms underlying ketamine's antidepressant effects.
Single IV antidepressant dose of ketamine hydrochloride (0.5 mg/kg).
Ketamine hydrochloride 0.5 mg/kg IV single infusion.
Single IV injection of inactive placebo (0.9% sodium chloride).
0.9% sodium chloride IV single injection (placebo).