Randomised, quadruple-blind, crossover study (n=28) of single oral doses of LSD (100 µg), MDMA (125 mg) and d‑amphetamine (40.3 mg) versus placebo in healthy volunteers to assess emotion processing and fMRI amygdala responses.
This randomized, quadruple-blind crossover study administers single oral doses of LSD, MDMA, d‑amphetamine and placebo to healthy adult volunteers to probe the roles of dopamine, serotonin and 5‑HT2A receptors in emotion processing.
Primary assessments include behavioural measures of empathy and mood perception alongside fMRI measures of amygdala activity to fearful stimuli; associations between subjective effects and imaging will be explored.
Each participant receives four single-dose sessions separated by washout; safety, vitals and adverse events are monitored throughout.
Within-subject crossover: placebo, LSD 100 µg, MDMA 125 mg, d-amphetamine 40.3 mg (each single oral dose; sessions separated by washout).
100 µg per os
125 mg per os
d-amphetamine sulfate 40.3 mg per os
Mannitol capsules identical appearance