Role Of Non-Specific Effects in The Treatment of Depression With Esketamine (ROSETTE)
This parallel assignment interventional trial (n=34 planned; 1 enrolled per registry) assesses whether pre‑treatment presentation and a post‑treatment follow-up improve expectation and response to esketamine for depressive episodes.
Details
The study tests whether a positive presentation before the first esketamine treatment improves patients' expectation of improvement within 24 hours after the first treatment.
A second aim is to determine whether a post‑treatment follow‑up session providing encouragement and reassurance improves expectation and clinical response (MADRS) within 24 hours and by the end of the acute esketamine course.
Parallel design comparing TAU versus pre‑/post‑treatment presentations plus TAU; outcome assessors collecting MADRS are masked (single‑blind).