Randomised, double‑blind, crossover study (n=13) administering MDMA (1.5 mg/kg) with and without citalopram (20 mg) in healthy volunteers to assess the role of serotonin in MDMA's emotional effects.
Randomised, double‑blind, crossover (2×2) study in healthy adult volunteers comparing single doses of MDMA (1.5 mg/kg) with placebo; citalopram 20 mg or placebo is co‑administered to attenuate MDMA‑induced serotonin release.
Primary aim is to measure MDMA's emotional and acute/subacute effects and determine how serotonin depletion by citalopram alters those effects; outcomes include subjective emotional measures and physiological safety assessments.
MDMA condition in 2×2 crossover with citalopram/placebo co‑administration.
MDMA 1.5 mg/kg; co‑administered with citalopram 20 mg or placebo per 2×2 crossover.
Citalopram 20 mg oral (pretreatment) when assigned; otherwise placebo.
Placebo condition in 2×2 crossover with citalopram/placebo co‑administration.
Placebo capsule; co‑administered with citalopram 20 mg or placebo per 2×2 crossover.
Citalopram 20 mg oral (pretreatment) when assigned; otherwise placebo.