Single-dose Ketamine for the Reduction of Pain and Depression in the Emergency Department

This parallel-group, randomised, quadruple-blind study will compare a single IV ketamine infusion (0.3 mg/kg) co-administered with midazolam to placebo plus midazolam in medically stable adults presenting to emergency departments with acute pain.

Outcomes include repeated measures of pain and mood in the ED (every 30 minutes), recording of analgesics given, and follow-up assessments of pain, mood, and analgesic use at 7 and 14 days post-discharge.