Study of IV Ketamine for Emergency Department Treatment of Adolescent Suicidal Ideation

Pilot randomised, quadruple-blind, placebo-controlled parallel trial testing a single 0.5 mg/kg IV ketamine infusion (max 50 mg over 40 minutes) versus saline in adolescents (12–17 years) presenting to the ED with acute suicidal ideation.

Primary objective is feasibility and preliminary efficacy for rapid reduction in suicidal ideation; outcomes include SI measures, safety, and short-term clinical course with follow-up as specified in the protocol.