Study Where Pharmaco Magnetic Resonance Imaging (MRI) Effects of AZD6765 Will be Compared to Placebo in Depressive Male and Female Subjects

This randomized study compares the pharmacological effects of a single infusion of AZD6765 versus ketamine and placebo on BOLD signal measured with fMRI in adults with major depressive disorder.

Primary purpose is basic science; three single-infusion arms (AZD6765, ketamine, placebo). Outcomes include fMRI BOLD responses and safety/tolerability measures; sites in Manchester and Oxford, UK.