Sub(acute) Profiling of 2C-B Versus Psilocybin

Randomised, double-blind, three-condition crossover in healthy volunteers (n=18) comparing single oral 20 mg 2C-B, 15 mg psilocybin and a 200 ml bitter lemon placebo; sessions separated by a two-week washout and each dosing day lasts ~6 hours.

Outcomes include acute cognitive and behavioural tasks, resting-state fMRI and MRS, intensive pharmacokinetics/metabolomics sampling, hourly subjective-effect ratings, and subacute follow-ups at 24 h and 5 days to profile persisting effects.