This double-blind, placebo-controlled crossover trial (n=60) investigates the effects of LSD on neural synchrony, prosocial behavior, and relationship quality in healthy romantic couples.
This randomised, double-blind, placebo-controlled 2-way crossover tests whether a single oral 50 µg dose of LSD enhances neural synchrony and prosocial behaviour in romantic couples (30 dyads).
Primary outcomes assess brain-to-brain synchrony using neuroimaging during dyadic tasks; secondary measures include prosocial task performance, relationship quality at follow-up, oxytocin and cytokine assays, and safety/tolerability assessments.
Participants receive both LSD and placebo in AB/BA sequence with a minimum 14-day washout; follow-ups occur 2 days (in-lab) and 4 days (at home) after dosing.
Single oral 50 µg LSD given in ethanol; part of 2-way crossover.
Administered in 2 mL 95% ethanol.
Identical ampule containing ethanol without LSD.
Identical ampule containing 1 mL 95% ethanol.