The Effect of Outpatient Ketamine Infusion on Chronic Neuropathic Pain and PTSD

Randomised, factorial, double-blind outpatient trial enrolling military-affiliated adults with chronic neuropathic pain to evaluate IV ketamine infusions (0.5 mg/kg/hr) alone or combined with magnesium, versus a magnesium control with delayed reassignment.

Infusions are administered in a diminishing schedule over 24 weeks (Weeks 1–2: 3/week; Weeks 3–4: 2/week; Weeks 5–6: 1/week; boosters at weeks 10 and 24). Outcomes include self-reported pain, PTSD questionnaires, anxiety, depression, quality of life, and medication use.