The Effects of Sedatives on Tobacco Use Disorder Version 2 (SED-TUD2)

This randomized, double-blind, crossover study delivers single intravenous infusions of ketamine, midazolam, dexmedetomidine, or saline at least two weeks apart to assess effects on cigarette smoking behaviour, craving, withdrawal and neural measures.

Participants complete 7-day ecological momentary assessment (EMA) periods before and after each infusion, abstain for 24 hours post-infusion with next-day MRI and behavioural assessments, and are closely monitored for physical and subjective adverse effects.