The effects of three small morning and evening doses of LSD on mood, biological and psychological measures of sleep, neuroplasticity, and well-being

Randomised, double-blind interventional study in healthy volunteers comparing three repeated morning versus evening microdoses of LSD (20 µg) against placebo in a factorial design; three dosing days are administered with interspersed non-dosing days.

Primary outcome is mood; secondary outcomes include measures of sleep, neuroplasticity (including BDNF and slow-wave sleep), cognitive performance, emotion regulation, markers of well-being, cortisol and endocannabinoid levels.