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The Neurobiological Effect of 5-HT2AR Modulation

RecruitingResults publishedRegisteredCTG

Non-randomised sequential experimental-medicine study (estimated n=200) using single oral doses of psilocybin and ketanserin to probe 5-HT2A receptor effects in healthy volunteers with PET and MRI outcomes.

Details

This experimental medicine project compares psilocybin (5-HT2A agonist) and ketanserin (5-HT2A antagonist) effects on brain function using MRI and multiple PET tracers (CIMBI-36, UCB-J) in healthy volunteers.

Design includes sequential allocation across subprojects examining receptor occupancy, long-term effects (1 and 12 week follow-ups), and functional connectivity with single oral dosing (25 mg specified in one subproject) and repeated neuroimaging assessments.

Topics:Healthy Volunteers

Registry

Registry linkNCT03289949