The role of 5-HT2 and 5-HT1A receptors in 3,4-methylenedioxymethamphetamine (MDMA) induced memory impairment and impulsivity.

Randomised, double-blind, double-dummy crossover in experienced MDMA users comparing six treatment conditions: MDMA 75 mg alone, MDMA+ketanserin 50 mg, MDMA+pindolol 20 mg, ketanserin alone, pindolol alone, and placebo.

Primary outcomes are neurocognitive measures of memory and impulse control assessed at Tmax; interventions synchronise Tmax using double-dummy administration.