The Role of 5-HT2A Receptor in the Perception of Self and Personal Meaning in Healthy Volunteers
Randomised, double-blind, placebo-controlled crossover fMRI study (n=25) testing single 100 µg oral LSD vs placebo and ketanserin (40 mg pretreatment) in healthy volunteers to probe 5-HT2A receptor contributions to self and personal meaning.
Details
This randomised, double-blind, placebo-controlled, cross-over trial in 25 healthy volunteers assesses the effects of single-dose oral LSD (100 µg) on self-consciousness, perception and meaning-making using functional magnetic resonance imaging, psychometric and cognitive measures.
The study includes a ketanserin pretreatment condition (40 mg) to evaluate the contribution of the 5-HT2A receptor; sessions use matched placebo capsules and standardised washout, with outcomes including neuroimaging correlates and behavioural/psychometric assessments.