This Phase II interventional trial (n=30), will investigate the efficacy of nitrous oxide in alleviating suicidal ideation (SI).
Randomised, double-blind, parallel-group Phase II study in psychiatric emergency department patients with active suicidal ideation comparing a single 60-minute inhalation of 50% nitrous oxide versus medical air.
Primary aim is rapid reduction in suicidal ideation; outcomes include validated suicidal ideation scales, safety/tolerability and short-term clinical course with follow-up assessments.
Inhaled medical air for 60 minutes (placebo comparator).
Inhaled medical air for 60 minutes (placebo comparator).
Inhaled nitrous oxide 50% for 60 minutes (active).
50% nitrous oxide inhaled for 60 minutes.