This study is dedicated to achieving better treatments for suicidal thoughts. Specifically, the investigators are studying the effect of a medication called ketamine to quickly treat suicidal thoughts and depression.
Pilot randomised, quadruple-blind, parallel-design study comparing a single IV infusion of ketamine (0.2 mg/kg) versus saline in patients with suicidal ideation and depression; includes cohorts with and without opioid use disorder.
The intervention is given in addition to usual psychiatric care; safety and change in suicidal ideation and depressive symptoms are primary outcomes in this small, proof-of-concept trial.
Patients with suicidal ideation and depression (no substance use disorder) receiving IV ketamine 0.2 mg/kg as a one-time dose.
Single IV infusion 0.2 mg/kg
Patients with suicidal ideation and depression (no substance use disorder) receiving comparable volume saline infusion.
Saline infusion (placebo)
Patients with suicidal ideation, depression and opioid use disorder receiving IV ketamine 0.2 mg/kg as a one-time dose.
Single IV infusion 0.2 mg/kg
Patients with suicidal ideation, depression and opioid use disorder receiving comparable volume saline infusion.
Saline infusion (placebo)