Compound Access
Country Access Report
Medical Access and Reimbursement in Ireland
Ireland remains clinically restrictive for classical psychedelics. Schedule 1 substances such as LSD, mescaline, DMT and psilocin are limited to narrow licensed purposes such as research, and psilocin-containing fungi have been controlled since 2006. The clear access route is intranasal esketamine: Spravato is EMA-authorised and HSE reimbursement was approved after price negotiations. Ketamine is Schedule 3, but depression use remains off-label and research-led.
- Access Level
- Reimbursed Esketamine + Research Only
- Compounds Covered
- 10
- Active Trials
- 2
Access by Compound
Compound-specific notes summarise what is realistically available through approved medical use, clinical research, exceptional access, or private care where the country report has verifiable information.
Compound Access
MDMA
Compound Access
Esketamine
Compound Access
Ketamine
Compound Access
DMT
DMT is listed in Schedule 1. No Irish authorised treatment or reimbursement route was identified outside licensed research. #
Compound Access
5-MeO-DMT
Compound Access
Ibogaine
The reviewed Irish materials did not establish an authorised ibogaine treatment or reimbursement route. Do not repeat blanket Schedule 1 wording unless the current consolidated statutory basis is manually confirmed. #
Compound Access
Ayahuasca
DMT is Schedule 1 and no official Irish ceremonial, medical or reimbursement pathway for ayahuasca was identified in reviewed sources. #
Compound Access
Mescaline
Mescaline is listed in Schedule 1. No Irish authorised treatment or reimbursement route was identified outside licensed research. #
Compound Access
2C-X
Ireland's Schedule 1 framework includes many phenethylamine derivatives, but the exact mapping for each 2C-family compound should be checked before publication. No authorised treatment or reimbursement route was identified. #
Sources and Verification
Last updated 14 May 2026. Source links are drawn from citation annotations in the medical access and reimbursement guide.
- 1EMA Spravato EPAR
- 2Ireland Misuse of Drugs Amendment Regulations 2006
- 3Ireland Misuse of Drugs Designation Order 2017
- 4Ireland Misuse of Drugs Regulations 2017
- 5medicines.ie Spravato SPC
- 6NCPE Spravato HTA page
- 7PubMed GH001 mebufotenin trial record
- 8PubMed KARMA-Dep 2 ketamine trial record
- 9Trinity COMP360 phase 2b news
- 10Trinity psychedelic clinical projects