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Academic Journal

Behavioural Pharmacology

3 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Psilocin and ketamine microdosing: effects of subchronic intermittent microdoses in the elevated plus-maze in male Wistar rats

This placebo-controlled rat study (n=40) investigated the effects of ketamine (0.5-3 mg/kg) and psilocin (0.05-0.075 mg/kg) microdosing (x3) on anxiety-related explorative behaviour in rats and found that both substances caused mild anxiety as measured by a reduction of explorative behaviour on an elevated open surface.

Published
Journal
Behavioural Pharmacology
Authors
Horsley, R. R., Páleníček, T., Kolin, J., Valeš, K.
Paywallindividual

Antidepressant, anxiolytic and procognitive effects of subacute and chronic ketamine in the chronic mild stress model of depression

In the chronic mild stress rat model, daily ketamine (optimal ~10 mg/kg) produced sustained antidepressant effects with onset at about one week—faster than imipramine—and both subacute and chronic regimens fully reversed CMS-induced anxiety-like behaviour and cognitive deficits. This demonstrates ketamine’s long-term antidepressant, anxiolytic and procognitive efficacy with notable translational potential.

Published
Journal
Behavioural Pharmacology
Authors
Papp, M., Gruca, P., Lason-Tyburkiewicz, M., Willner, P.
Open Accessindividual

Sex differences and serotonergic mechanisms in the behavioural effects of psilocin

In rats, psilocin produced dose‑dependent locomotor suppression, behavioural serotonin syndrome and impaired prepulse inhibition, with effects more pronounced in males. The locomotor inhibition was normalised by 5‑HT1A and 5‑HT2B/C antagonists while PPI deficits were not, indicating sex‑specific behavioural responses and a role for 5‑HT1A and 5‑HT2B/C receptors in addition to 5‑HT2A.

Published
Journal
Behavioural Pharmacology
Authors
Tylš, F., Páleníček, T., Kadeřábek, L., Lipski, M., Kubešová, A., Horáček, J.

Quick Facts

Papers Indexed
3
h-Index
90
Open Access
No
Publisher
Wolters Kluwer
Country
United States
Website
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