In rats, psilocin produced dose‑dependent locomotor suppression, behavioural serotonin syndrome and impaired prepulse inhibition, with effects more pronounced in males. The locomotor inhibition was normalised by 5‑HT1A and 5‑HT2B/C antagonists while PPI deficits were not, indicating sex‑specific behavioural responses and a role for 5‑HT1A and 5‑HT2B/C receptors in addition to 5‑HT2A.
- Published
- Journal
- Behavioural Pharmacology
- Authors
- Tylš, F., Páleníček, T., Kadeřábek, L., Lipski, M., Kubešová, A., Horáček, J.