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British Journal of Pharmacology

2 Papers Indexed in Blossom

Published Papers

Open Accessindividual

4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes

In Xenopus laevis oocytes expressing rat receptors, 2,5‑dimethoxy‑4‑substituted phenethylamines (including 2C‑B) behaved as potent, subtype‑selective 5‑HT2A antagonists—blocking 5‑HT‑induced currents (maximal after ~2 min preincubation) but not affecting 5‑HT2C—with antagonist potency ranked 2C‑I > 2C‑B > 2C‑D > 2C‑H. The authors suggest these results mean the psychostimulant actions of these PEAs may not be solely due to 5‑HT2A agonism.

Published
Journal
British Journal of Pharmacology
Authors
Villalobos, C. A., Bull, P., Sa´ez, P., Cassels, B. K., Huidobro-Toro, J. P.
Open Accessmeta

Gaddum and LSD: the birth and growth of experimental and clinical neuropharmacology research on 5-HT in the UK

This review documents how a small group of UK scientists in the two decades after serotonin's identification developed assays, characterised its synthesis and metabolism, and demonstrated LSD's antagonism and drug effects on brain 5‑HT. Their work established serotonin's putative role in mood regulation and laid the foundations for modern ideas about how antidepressant drugs act.

Published
Journal
British Journal of Pharmacology
Authors
Green, A. R.

Quick Facts

Papers Indexed
2
h-Index
252
Open Access
No
Publisher
Wiley
Country
United States
Website
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