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Cell

5 Papers Indexed in Blossom

Published Papers

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Psychedelic-inspired drug discovery using an engineered biosensor

This study describes the development and use of an engineered biosensor (PsychLight) that detects relevant serotonin release to predict the hallucinogenic behavioral effects of psychedelics. This tool is used to identify non-hallucinogenic psychedelic compounds that still elicit antidepressant-like effects.

Published
Journal
Cell
Authors
Dong, C., Ly, C., Dunlap, L. E., Wetsel, W. C., Olson, D. E., Tian, L., Vargas, M. V., Sun, J., Hwang, I. W., Azinfar, A., Oh, W. C.
Open Accessindividual

Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

This study reveals structurally how psychedelics, including LSD, psilocin, mescaline, and various N-BOH analogs, mediate their therapeutic and hallucinogenic effects by binding to and activating their molecular target, the serotonin (5-HT) 2A receptor coupled with G-protein Gaq.

Published
Journal
Cell
Authors
Kim, K., Che, T., Panova, O., Shoichet, B. K., Skiniotis, G., Roth, B. L., Diberto, J. F., Lyu, J., Krumm, B. E., Wacker, D., Robertson, M. J., Seven, A. B., Nichols, D. E.
Open Accessmeta

Psychedelic Psychiatry’s Brave New World

This popular commentary article (2020) describes the current resurrection of research into psychedelics (both neuroscience and therapeutic applications). It describes the evidence for the serotonin receptor (5-HT2a) agonism (psychedelics binding to that receptor) and the possible mechanisms through which long-lasting therapeutic effects can be found.

Published
Journal
Cell
Authors
Nutt, D. J., Erritzoe, D., Carhart-Harris, R. L.
Open Accessindividual

Crystal Structure of an LSD-Bound Human Serotonin Receptor

This crystallography study analyzed the structure of LSD bound to a serotonin receptor and found that a branch of the receptor folds over the molecule while it is lodged into the binding pocket, and this lid-like structure secures LSD in place. This contributes to a slow dissociation rate of LSD, which forms the basis for its long-lasting effect. The authors suggest ways of introducing molecular mutations to selectively alter receptor signaling by increasing the mobility of this lid structure.

Published
Journal
Cell
Authors
Wacker, D., Wang, S., Mccorvy, J. D., Shoichet, B. K., Dror, R. O., Roth, B. L., Betz, R. M., Venkatakrishnan, A. J., Levit, A., Lansu, K., Schools, Z. L., Che, T., Nichols, D. E.
Open Accessmeta

MDMA as a Probe and Treatment for Social Behaviors

This commentary (2016) reviews the history of MDMA and argues for the further exploration of MDMA's mechanism of action.

Published
Journal
Cell
Authors
Heifets, B. D., Malenka, R. C.

Quick Facts

Papers Indexed
5
h-Index
925
Open Access
No
Publisher
Elsevier
Country
United States
Website
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