This study reveals structurally how psychedelics, including LSD, psilocin, mescaline, and various N-BOH analogs, mediate their therapeutic and hallucinogenic effects by binding to and activating their molecular target, the serotonin (5-HT) 2A receptor coupled with G-protein Gaq.
- Published
- Journal
- Cell
- Authors
- Kim, K., Che, T., Panova, O., Shoichet, B. K., Skiniotis, G., Roth, B. L., Diberto, J. F., Lyu, J., Krumm, B. E., Wacker, D., Robertson, M. J., Seven, A. B., Nichols, D. E.