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Chronic Stress

4 Papers Indexed in Blossom

Published Papers

Open Accessindividual

Increases in Psychological Flexibility Mediate Relationship Between Acute Psychedelic Effects and Decreases in Racial Trauma Symptoms Among People of Color

In a cross-sectional survey of 313 BIPOC, greater acute psychedelic insight and challenging experiences were associated with reductions in racial trauma symptoms, and increases in psychological flexibility partially mediated these relationships. The authors suggest psychedelics may reduce racial trauma among people of colour via enhanced psychological flexibility and recommend longitudinal clinical trials to test causality.

Published
Journal
Chronic Stress
Authors
Davis, A. K., Xin, Y., Sepeda, N. D., Garcia-Romeu, A., Williams, M. T.
Open Accessindividual

Using Psychedelics With Therapeutic Intent Is Associated With Lower Shame and Complex Trauma Symptoms in Adults With Histories of Child Maltreatment

In a survey of 166 adults with histories of child maltreatment, intentional therapeutic use of psychedelics was associated with significantly lower complex trauma symptoms and lower internalised shame despite similar maltreatment histories. Differences were largest in participants reporting more than five therapeutic uses—who also showed a moderating effect on the link between emotional abuse/neglect and complex trauma—while no associations were found with facial emotion recognition.

Published
Journal
Chronic Stress
Authors
Healy, C. J., Lee, K. A.
Open Accessindividual

Psychedelic Treatment for Trauma-Related Psychological and Cognitive Impairment Among US Special Operations Forces Veterans

In a retrospective survey of 51 U.S. Special Operations Forces veterans who completed a psychedelic programme in Mexico (ibogaine and 5‑MeO‑DMT), participants reported very large reductions in suicidal ideation, PTSD, depression, anxiety and cognitive impairment alongside large increases in psychological flexibility. These preliminary, self‑reported findings are limited by retrospective design and lack of randomisation/blinding, so controlled trials are needed to establish efficacy.

Published
Journal
Chronic Stress
Authors
Davis, A. K., Averill, L. A., Sepeda, N. D., Barsuglia, J. P., Amoroso, T.
Open Accessmeta

The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?

This review (2018) examines the neurobiology of depression in light of the rapid fast-acting antidepressant properties of ketamine, with particular regard for the role of inhibitory and excitatory glutamate transmission. It is evident that the primary mechanism of ketamine is the induction of transient (minutes-to-hours) postsynaptic glutamate activation, which ultimately leads to a sustained (days-to-weeks) increase in synaptic formation and strength in the prefrontal cortex. However, it is unclear whether ketamine's effects on glutaminergic inhibition via extrasynaptic NMDA) receptors exert rapid or even slow antidepressant effects.

Published
Journal
Chronic Stress
Authors
Abdallah, C. G., Sanacora, G., Duman, R. S., Krystal, J. H.

Quick Facts

Papers Indexed
4
h-Index
31
Open Access
Yes
Publisher
SAGE Publications
Country
United States
Website
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